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Materia Medica Sources for Physostigma

T.F. AllenBoericke ✔BogerClarkeReversed & reworded Kent repertory ✔

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Calabar Bean, Physostigma Venenosum

Boiron and HomeodelWHP - Washington HomeopathicHylands and Standard Homeopathic
Available in 5X-30X, 200X, 3C-30C, 200C, 1M-50M, CM from $6.50
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HPUS indication: Stiff neck

Homeopathic remedies are prescribed on the basis that in a tiny dilution like cures like, so while the very dilute homeopathic remedy may help, the raw product is often best avoided.

Below are the strongest indications (i.e. symptoms) of Physostigma in traditional homeopathic usage, not reviewed by the FDA.



This remedy and its active principle, Eserine N/A , form a valuable addition to Materia Medica. Stimulates heart, raises blood pressure, and increases peristalsis. Causes contraction of the pupil and of the ciliary muscles. Induces a condition of short-sightedness. Spinal irritation, loss of motility, prostration, with very sensitive vertebrae. Fibrillary tremors. Rigidity of muscles; paralysis. Depresses the motor and reflex activity of the cord and causes loss of sensibility to pain, muscular weakness, followed by complete paralysis, although muscular contractility is not impaired. Paralysis and tremors, chorea. Meningeal irritation, with rigidity of muscles. TETANUS and trismus. Poly myelitis anterior. Eserine is used locally to produce contraction of pupil.


Third potency. The neutral sulphate of Eserine N/A is instilled into the eye, from one-half to four grains to one ounce distilled water, to induce Contraction of pupil, in mydriasis, injuries to the eye, iritis, corneal ulcers

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Compare: Eserine N/A - the alkaloid of Physostigma - (slows action of heart and increases arterial tension; in ciliary spasm and spasmodic Astigmatism due to irregular action of ciliary muscles; blepharo-spasms; Pupils contracted. Twitching of lids, soreness of eyeballs, blurring of vision After using eyes, pains around eyes and head). Used locally to contract the pupil. ESERINE contracts the pupils dilated by Atropine, but not those dilated by Gelsemium Sempervirens Gelsemium. Internally 6X. Eserin salicylate (post-operative intestinal paralysis; meteorism. Hypodermically 1/60-1/40 gr).

Compare also: Muscarin; Conium Mac Conium; Curare Curare; Gelsemium Sempervirens Gels.; Thebainum (tetanus); Piperazinum N/A - (Uric acid conditions. Pruritus. Gout and urinary calculi. Constant backache. Skin dry, urine scanty. Rheumatic arthritis. Give one grain daily in carbonated water. First and second decimal trituration three times a day.)


Antidote: Atropia N/A . In full medicinal doses will relieve most of the effects of Physostigmine.

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Constant pain on top; vertigo, with constrictive feeling of head

Pain over orbits; Cannot bear to raise eyelids

Spastic conditions of the face-muscles.

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Night-blindness (Opposite: Bothrops Lanceolatus Bothrops); photophobia; Contraction of pupils; twitching of ocular muscles


Muscae volitantes; flashes of light; partial blindness

Glaucoma; paresis of accommodation; astigmatism

Profuse lachrymation

Spasm of ciliary muscle, with irritability after using eyes

increasing myopia

Post-diphtheritic paralysis of eye and accommodation muscles.

Twitching; lids


Colours and shapes in front of eyes; colours; black; spots; floating (aka muscae volitantes or spiders)



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Fluent coryza; burning and tingling of nostrils; nose stuffed and hot

Fever-blisters around nostrils.

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Tongue feels sore on tip

Feeling as if a ball came up throat.

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Strong heart-pulsation felt in throat.

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Heart; Feeble pulse; palpitation; spasmodic action, with feeling of pulsation through the whole body

Beats of heart distinctly perceptible in chest and head

Fluttering of heart felt in throat

Fatty degeneration ( Cup-ac.)

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Stomach; Great pain immediately after eating

Sensitive to pressure in epigastric region

Pain extends into chest and down arms

Gastralgia.; chronic constipation.

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Female; Irregular menstruation, with palpitation

Congestion of eyes

Rigid muscles.

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Extremities, limbs

Pain in right popliteal space

Burning and tingling in spine

Hands and feet numb

Sudden jerking of limbs on going to sleep

Tetanic convulsions

Locomotor ataxia

Numbness in paralyzed parts, crampy pains in limbs.

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Tension; muscles

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