Depression, Psychological and mental state

Hi all,

Need Help, One of my cousin is suffering from depression since last 15 years. She is fair and fatty. She has the following problem:
1. she feels that the toilet is dirty and always go for motion in open field and can not tolertae the toilet pan in the house.
2.she always feels that her hands are dirty and keeps on cleaning her hand. the hands have become white due to regular contact of water.
3. she feels that an insect has made its dwelling in the corner of every room and neighbours building and she tries to clean it with a knife and spoils the walls.
4.she always stays at home and whenever she comes out she closes her eyes that every where is dirty and on the main road she opens her eyes and considers it to be clean. In this process she always hurt herself.
5.She keeps on crying consdering that no body will take care of her in future as she is not normal.
6.her mother and brothers also have the same problem.
7. She is under Pshycriatic treatment since last ten years without any development. she also takes sleeping pills regularly as she does not get sleep